Bianca (Mae Whitman) is a content high school senior whose world is shattered when she learns the student body refers to her as 'The DUFF' (Designated Ugly Fat Friend) to her prettier, more popular friends (Skyler Samuels & Bianca Santos). With her universe turned upside down, she ignores words of wisdom from her favourite teacher (Ken Jeong) and enlists Wesley (Robbie Amell), a slick but charming jock, to help set her apart from the pack and erase her label forever. In doing so, she hopes to land her crush Toby (Nick Eversman), and find the confidence to overthrow the school's ruthless label maker Madison (Bella Thorne) by reminding everyone that no matter what people look or act like, we are all someone's DUFF...and that's totally fine.